Meet the Site’s Host

After working as a researcher (short time, PhD program on immunology), a clinical pathologist (some time), an anatomical pathologist (long time, around twenty years), and pathologists’ assistant (more than five years), I found my most productive niche as a grossing technologist at the Department of Pathology Loyola University Chicago Medical Center. Here I had an opportunity to summarize my pathology experience, formulate some principles of grossing technology, and propose some “inventions”, namely gadgets, which might be useful in practice.  Actually, most of my “revelations” may already existed, but either there was no information published about them  or they had been forgotten.

A fledgling sub-specialty emerges in the surgical pathology laboratory when grossing is assigned to laboratory workers, most often histotechnologists, who do not have systematic pathology education as well as the skills to perform this initial stage of processing, crucial to a pathologist’s diagnosis. Right or wrong, this is a fact of life. In my publications and workshops (Publications in the USA, see below), I have relentlessly promoted grossing technology as a sub-specialty that extends beyond specimen sampling techniques, but includes many aspects of the initial phase specimen processing before histotechnology begins per se.

New technologies have brought grossing technology, the initial stage of specimen processing, additional challenges from microdissection for molecular technology to standardization for Whole Slide Imaging (WSI) digital pathology. Adequate specimen preservation and appropriate orientation for optimal diagnostic results during sampling become especially important for modern and future anatomic pathology laboratories.  This is a still-uncharted territory of grossing technology that requires attention and development.

The website opens opportunities to express my own views without sensing a reviewer’s disapproving eye . My web home is my castle as the old British might have said if they had known the Internet.

My site is my home on World Wide Web (www). My home on the Internet is


Publications in the USA

Publications on grossing technology and beyond 

In Seth L. Haber’s column “Innovation in Pathology”: Handling bones and other calcified tissue – CAP TODAY September 2003; December 2003; March 2004.

Dimenstein IB: Baby Diaper Pad for Filtration Biopsies. The Journal of Histotechnology 2006; Vol 29, No. 3. P.204.

Dimenstein IB: Hard Pressed Cardboard for Bone Grossing Immobilization. AAPA Newsletter, 2007 Vol. XXXV No.4:25.

Dimenstein IB: Bone grossing techniques: helpful hints and procedures. Annals of Diagnostic Pathology 2008; 12:191-198.

Dimenstein IB: Root Cause Analysis of Specimen Misidentification in Surgical Pathology Accession and Grossing. LabMedicine 2008; 39: 497-502.

Dimenstein IB: Incision in a Foam Pad for Embedding Orientation. The Journal of Histotechnology 2008; 31: 141-142.

Dimenstein IB: Grossing biopsies: an introduction to general principles and techniques. Annals of Diagnostic Pathology2009; 13: 106-113.

Dimenstein IB: New Devices for Manual Embedding Orientation. The Journal of Histotechnology 2009; Vol. 32 (3): 123-125.

Dimenstein IB: A Pragmatic Approach to Formalin Safety in Anatomical Pathology. LabMedicine 2009 Vol. 40 (12):740-746.

Dimenstein IB:  “The Grossing Histotechnologist in Surgical Pathology” (Two installments) Advance for Administrators of the Laboratory online edition 2010 May 10th and 20th.

Dimenstein IB: Sectionable cassette for embedding automation in surgical pathology. Annals of Diagnostic Pathology 2010; 14:100-106.

Dimenstein IB: Specialized Stations for Grossing Biopsies. The Cutting Edge Journal. AAPA 2011Vol.1. 1: 20-22.

Dimenstein IB: Gadgets for ‘Floaters’ prevention in the histopathology laboratory. The Journal of Histotechnology 2011; Vol. 34, 2: 88-90.

Dimenstein IB: Decalcification in surgical pathology. The Cutting Edge Journal. AAPA 2012. Vol. 2. 3: 21-23.

Dimenstein IB: Third-hand Immobilization in Gross Sectioning of Pathology Specimens. HistoLogic, June, 2013, 8-10.

Dimenstein IB: The concept of adjustable immobilization to aid grossing and facilitate uniform biopsy slices. Technical Note. 2013; Journal of Histotechnology; Vol. 36, Number 3:106-109.

Dimenstein IB: Grossing Histotechnologist Training. Guest Editorial. Journal of Histotechnology. 2015, Vol. 38, No. 2, pages 33-38.

Dimenstein IB: The complete prostate needle biopsy submission during grossing and embedding. Journal of Histotechnology, 2016, Volume 39, Issue 3, pp. 76-80.

Dimenstein IB: Embedding automation methods: perspective and prospects. Annals of Diagnostic Pathology 2019; 42:12-17.

Dimenstein IB: Grossing Technology Today and Tomorrow. Laboratory Medicine, Volume 51, Issue 4, July 2020, Pages 337–344.

Dimenstein IB: The road from cytotoxins to immunohistochemistry. Journal of Histotechnology. Published online: 10 Sep 2020 Download citation

Dimenstein IB Hybrid Autopsy Virology Laboratory Experimental Platform. J Infect Dis Epidemiol (2020) 6:180.

Dimenstein IB. (2021) The Concept of a Compound Autopsy Experimental Laboratory for SARS-CoV-2 Aerosolization Studies. International Journal of Clinical and Experimental Medicine Research, 5(2), 161-165.                               DOI:

Dimenstein I. B., Churilov L. P. Alexander A. Bogomolet’s’ and his followers’ cytotoxins studies legacy.                              Clinical Pathophysiology, 2021 Volume 27, Issue 4. 2021


Clifford M. Chapman & Izak B. Dimenstein. Dermatopathology Laboratory Techniques. 2016. CreateSpace Publication. ISBN-13: 978-1535366878.

Dimenstein Izak. Grossing Bones: Principle, Techniques, and Instruments. 2017. CreateSpace Publication. ISBN-13:978-1548490799.

Dimenstein Izak. Grossing Technology. A Guide for Biopsies and Small Specimens. 2018. CreateSpace Publication ISBN-13:978-1725672314.

Dimenstein Izak. Skin Grossing in Histology Laboratories. 2020. CreateSpace Publication ISBN-13:979-8627885810.

Publications on CPT® coding

Letter to the Editor: “Billing, coding errors.” CAP TODAY October 2002 pp. 8, 11

Letter to the Editor:”Questionable Recommendations” on the article “Cutting Expenses in Anatomical Pathology”.  Advance for Medical Laboratory Professionals 2002 December 2. pp.  11, 19

Dimenstein IB: Preventing Unintentional Overcharge. Advance for Administrators of the Laboratory, August 2004, p.20

Dimenstein IB: CPT Coding for Soft Tissue Tumors. Advance for Administrators of the Laboratory. November 2005: 16-18

Dimenstein IB: Lymph Node Coding in Surgical Pathology. LabMedicine 2005; 36: 602-603

Letter to the Editor: “The Other Side of Compliance.” LabMedicine 2005; 36: 122

Dimenstein IB: CPT Coding for Mastectomy (A Case Study). LabMedicine 2006; Vol. 37(11): 654-656

Dimenstein IB: CPT Coding in Dermatopathology. LabMedicine2009; 40: 151-156

Dimenstein IB: Principles and Controversies in CPT Coding in Surgical Pathology. LabMedicine 2011; 42: 242-249 Author’s Response. LabMedicine 2011; 42: 376

Dimenstein IB: IHC coding changes. Letter to the Editor. CAP TODAY, 2014, February, Page 6.


Dimenstein Izak B. Procedural Coding in Anatomic Pathology. 2018. CreateSpace Publication. ISBN-13: 978-1987700602.

Publications on educationl laboratory website 

Dimenstein IB, Dimenstein SI: Development of a Laboratory Niche Website. Annals of Diagnostic Pathology, 17 (2013) 448-456.

Dimenstein IB and Dimenstein SI: Poster abstract. The “Nested Doll” principle in the development of an educational laboratory niche website” NSH Symposium /Convention, Providence, September, Journal of Histotechnology, 2013, vol.36, No.4, page 147. American Journal of Clinical Pathology, Volume 140, Issue suppl_1, 1 September 2013, Pages A232, Published: 21 October 2015

Dimenstein IB: Poster “Building a Laboratory Educational Niche Website” AAPA’s Educational Conference, New York, NY, September, 2014.

Dimenstein IB, Dimenstein SI: Laboratory educational websites as facilitators of information exchange. J Health Med Information; 2014; V5 Issue 3; Page 87.

Dimenstein IB: Laboratory Educational Authority Website Development. International Journal of Education and Information Technology Volume 2, Issue 2, April 2016, pages 8-13.

Dimenstein I: Laboratory Websites Portals as Pathology Educational Resources: The Concept of Combining Apples and Oranges with other Fruits. J Pathol Inform 2016, 7:33 Pathology Informatics Summit 2016.

Dimenstein I: The Portal Design of Educational Pathology Laboratory Websites. American Journal of Clinical Pathology, Volume 146, Issue suppl_1, 1 September 2016,130,

Dimenstein IB: Technical Note: Experience of maintaining laboratory educational website’s sustainability. J Pathol Inform 2016, 7:37 (1 September 2016)DOI:10.4103/2153-3539.189702;year=2016;…








Gross pathology is usually defined as macroscopic appearance of diseases in surgical pathology and autopsy. From the old days of medicine, it has been the bedrock of anatomic pathology. It is breathtaking how far science, medicine, and pathology went away from gross appearances by diving deep into molecular and sub-molecular analysis. The enormous amount of new scientific and clinical data beg for comprehensive approaches and interpretation. Where is the distinction between normal physiology and pathology, disease and function disorders? When is the event an accidental occurrence or a pathology pattern? What is the balance between the cause and condition in pathology?

The Gross Pathology website intends to address basic pathology issues from the host’s perspective as an experimental researcher, clinical and anatomic pathologist, pathologists’ assistant and grossing technologist. An evolutionary approach could contribute to better understanding of pathology issues. The website also will return to concepts partially or completely forgotten which were at the foundation of modern pathology. One of them is the concept of functional pathology.

The predecessor of the Gross Pathology website was our Grossing Technology in Surgical Pathology website which had been quite popular during more than a decade. The Gross Pathology website will maintain only a fraction of previous website. A separate section “Laboratory website” addresses some details of maintaining a sustainable educational laboratory niche website. Our previous Grossing Technology in Surgical Pathology website has been taken as an example. Although the development of an educational website follows the building pattern of a regular informative website, a laboratory educational website has some particularities.

Our book Grossing Technology. A Guide for Biopsies and Small Specimens (Amazon. com)  introduces general principles of grossing technology and their application in histology laboratory practice. It encompasses all activities in the surgical pathology histology laboratory during the pre-analytical stage of specimen processing. The Special part of the book concentrates on technical details of grossing predominately biopsies and small (“routine”) specimens. The book accumulates the experiences of a variety of histology laboratories, from academic institutions to large commercial and small standalone laboratories. The materials can be used for grossing technologists training programs.

Materials on bone grossing are in more details in our book Grossing Bones: Principles, Techniques, and Instruments available now on This book is my favorite because it includes many my technical “revelations.” I updated the book in an ebook form.

The  published Skin Grossing in Histology Laboratories book,  available now on, summarizes skin grossing technology of most frequent grossing situations  with additional chapters on more complicated skin specimens.

 Current Procedural Terminology (CPT) coding  is presented in a summarized form in the book Procedural Coding in Anatomic Pathology  ( This book is the most popular among all my books. Perhaps, it clarifies complicated CPT coding issues in simple graphic form. When the book has been purchased as a package of 10, probably it was for educational purpose.  Amazon does not disclose the purchaser.

During COVID-19 pandemic, I have summarized by experience as a infectious disease epidemiologist, experimental immunologist, and anatomical pathology practitioner in two books: Black Swan’s Questions for Covid-19 and Protective Mask, published on Kindle Direct. While digestion the Covid-19 handling experience, these books are focused on rational approaches to viruses epidemics in the future.

The prices for my books are minimal allowed by I am interested in the dissemination of my experience.

The domain of the  “Grossing  Technology in Surgical Pathology” website is intentionally left the same with the hope that the previous website’s friends will return to explore new avenues beyond practical utility applications in grossing technology. Comments and suggestions are highly welcomed

Copyright © 2022 by Izak B. Dimenstein  All rights reserved